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AZILECT® FAQs
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AZILECT® FAQs

How does AZILECT® work, and what are some of its benefits?

How do I take AZILECT® ? 

Who should not take AZILECT®? 

Are there side effects with AZILECT® treatment?

 

Are there any foods or beverages I should avoid?

What about other medications I might need?



How does AZILECT® work, and what are some of its benefits?

Over time, Parkinson's disease will cause you to lose more and more dopamine in your brain.

 

AZILECT® works by blocking the breakdown of dopamine in the brain. As much as 60% to 80% of dopamine could be lost by the time PD is diagnosed.

 

With more dopamine available in your brain, you may be able to move more freely again. Everyday tasks may become less difficult.

 

AZILECT® is the first once-daily medication for the treatment of PD.

  • One AZILECT® pill per day helps relieve many of the troubling symptoms of PD.
  • AZILECT® may be taken alone or in combination with other PD medications.
  • AZILECT® therapy is well tolerated.

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How do I take AZILECT®?

AZILECT® has been shown to work for patients when taken alone for symptom relief in early stage PD or when taken with carbidopa/levodopa and other PD medications when more relief is needed. Your AZILECT® dosing is convenient:

  • Take one pill just once daily—whether you’re new to PD therapy or have been taking other PD medications for years.
  • AZILECT® can be taken with or without food.
  • If you miss a dose, don’t double up, just take your next dose as scheduled.
  • You should avoid certain foods, beverages, dietary supplements, and cold remedies. This is important in order to prevent a possibly dangerous rise in blood pressure called a hypertensive crisis. (Foods to avoid).  

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Who should not take AZILECT®?

You should not take AZILECT®:

  • if you are currently taking meperidine as it could possibly result in a serious reaction such as coma or death.
  • with tramadol, methadone, propoxyphene, dextromethorphan, St. John’s wort, mirtazapine, or cyclobenzaprine.
  • with other monoamine oxidase inhibitors (MAOIs), amphetamines, cold remedies containing decongestants and weight-reducing preparations containing pseudoephedrine, phenylephrine, phenylpropanolamine, or ephedrine in order to avoid a possibly dangerous rise in blood pressure.

Symptoms of a dangerous rise in blood pressure include severe headache, blurred vision, difficulty thinking, seizures, chest pain, unexplained nausea or vomiting, or signs or symptoms of a stroke.
You or your caregiver should seek immediate medical attention if these symptoms or other unusual symptoms occur.

  • if you have moderate to severe liver disease or a tumor of the adrenal gland.

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Are there side effects with AZILECT® treatment?

AZILECT® is generally well tolerated. Side effects seen with AZILECT® alone are headache, joint pain, and indigestion. Side effects seen with AZILECT® taken with levodopa are uncontrolled movements (dyskinesias), accidental injury, nausea, weight loss, constipation, low blood pressure when standing, joint pain, vomiting, dry mouth, rash, and sleepiness. Be sure to tell your doctor about these and any other side effects you experience when taking AZILECT®.

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Are there any foods or beverages I should avoid?

When taking AZILECT®, you should avoid foods and beverages high in a substance called tyramine to prevent a possibly dangerous rise in blood pressure. (See symptoms) 

The following table provides a list of some common foods and beverages that are high in tyramine, along with suggested alternatives, or view the printable tyramine fact card.

In order to view the fact card, you will need Adobe® Reader®. For a FREE download of Adobe® Reader®, click here.

 

Type of food or beverage

AVOID these tyramine-rich foods and beverages

CHOOSE a food that contains little or no tyramine

Meat, poultry, and fish

Air-dried, aged, and fermented meats, sausages, and salami (including cacciatore, hard salami, and mortadella)

Pickled herring
Any spoiled or improperly stored meat, poultry, and fish (for example, foods that have undergone changes in coloration or odor or become moldy)

Spoiled or improperly stored animal livers

Fresh meat, poultry, and fish

Fresh processed meats (for example, lunch meats, hot dogs, breakfast sausage, and cooked sliced ham)

Vegetables/Misc.

Broad bean pods (fava bean pods)

Sauerkraut
Most soybean products (including soy sauce and tofu)

All other vegetables

Soy milk

Commercial chain-restaurant pizzas prepared with cheeses low in tyramine

Dairy

Aged cheeses, such as cheddar, English Stilton, Swiss, and blue cheese

Processed cheese (for example, American cheese slices, Velveeta®, and Cheez Whiz®)

Cream cheese

Mozzarella

Ricotta cheese

Cottage cheese

Yogurt

 

Beverages

All varieties of tap beer and beer that has not been pasteurized so as to allow for ongoing fermentation

Bottled and canned beer

Velveeta® and Cheez Whiz® are registered trademarks of their respective owners.

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What about other medications I might need?

Be sure you talk to your doctor before starting AZILECT®  if you are taking, or planning to take, any over-the-counter or prescription medications, especially antidepressants and ciprofloxacin.

In addition, when taking AZILECT® , you should not have elective surgery requiring general anesthesia, and you should not receive cocaine or other local anesthesia that contains ingredients that could raise blood pressure.

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